Hedstrom, Lizbeth: search on Z-Library

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1

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

Checkley, William, White, A Clinton, Jaganath, Devan, Arrowood, Michael J, Chalmers, Rachel M, Chen, Xian-Ming, Fayer, Ronald, Griffiths, Jeffrey K, Guerrant, Richard L, Hedstrom, Lizbeth, Huston, Chr

Journal:

The Lancet Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 148 KB

english, 2015

2

Serine Protease Mechanism and Specificity

Hedstrom, Lizbeth

Journal:

Chemical Reviews

Year:

2002

Language:

english

File:

PDF, 306 KB

english, 2002

3

The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α) 8 barrel enzymes

Hedstrom, Lizbeth

Journal:

Critical Reviews in Biochemistry and Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

4

The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity

MacPherson, Iain S., Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Riera, Thomas V., D’Aquino, J. Alejandro, Zhang, Minjia, Cuny, Gregory D., Hedstrom, Lizbeth

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 1.96 MB

english, 2010

5

Structural Determinants of Inhibitor Selectivity in Prokaryotic IMP Dehydrogenases

Deviprasad R. Gollapalli, Iain S. MacPherson, George Liechti, Suresh Kumar Gorla, Joanna B. Goldberg, Lizbeth Hedstrom

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1.24 MB

english, 2010

6

Magnetic nanoparticles for direct protein sorting inside live cells

Pan, Yue, Long, Marcus J. C., Lin, Hsin-Chieh, Hedstrom, Lizbeth, Xu, Bing

Journal:

Chemical Science

Year:

2012

Language:

english

File:

PDF, 274 KB

english, 2012

7

Structural origins of substrate discrimination in trypsin and chymotrypsin

Perona, John J., Hedstrom, Lizbeth, Rutter, William J., Fletterick, Robert J.

Journal:

Year:

1995

Language:

english

File:

PDF, 5.16 MB

english, 1995

8

Triazole Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

Maurya, Sushil K., Gollapalli, Deviprasad R., Kirubakaran, Shivapriya, Zhang, Minjia, Johnson, Corey R., Benjamin, Nicole N., Hedstrom, Lizbeth, Cuny, Gregory D.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 837 KB

english, 2009

9

Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

Sivapriya Kirubakaran, Suresh Kumar Gorla, Lisa Sharling, Minjia Zhang, Xiaoping Liu, Soumya S. Ray, Iain S. MacPherson, Boris Striepen, Lizbeth Hedstrom, Gregory D. Cuny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 777 KB

english, 2012

10

Multivalent Glycocluster Design through Directed Evolution

Dr. Iain S. MacPherson, J. Sebastian Temme, Sevan Habeshian, Dr. Krzysztof Felczak, Prof. Krzysztof Pankiewicz, Lizbeth Hedstrom, Prof. Isaac J. Krauss

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 1.29 MB

english, 2011

11

Is Arg418 the Catalytic Base Required for the Hydrolysis Step of the IMP Dehydrogenase Reaction? †

Guillén Schlippe, Yollete V., Hedstrom, Lizbeth

Journal:

Year:

2005

Language:

english

File:

PDF, 249 KB

english, 2005

12

Cell Compatible Trimethoprim-Decorated Iron Oxide Nanoparticles Bind Dihydrofolate Reductase for Magnetically Modulating Focal Adhesion of Mammalian Cells

Long, Marcus J. C., Pan, Yue, Lin, Hsin-Chieh, Hedstrom, Lizbeth, Xu, Bing

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 2.31 MB

english, 2011

13

Mycophenolic acid and thiazole adenine dinucleotide inhibition of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: implications on enzyme mechanism

Hedstrom, Lizbeth, Wang, Ching C.

Journal:

Year:

1990

Language:

english

File:

PDF, 658 KB

english, 1990

14

Comparison of anionic and cationic trypsinogens: The anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure

Annette Pasternak, Dagmar Ringe, Lizbeth Hedstrom

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 313 KB

english, 1999

15

Purine base transport in wild-type and mycophenolic acid-resistant Tritrichomonas foetus

Lizbeth Hedstrom, Ching C. Wang

Journal:

Molecular and Biochemical Parasitology

Year:

1989

Language:

english

File:

PDF, 666 KB

english, 1989

16

Structure−Activity Studies of the Inhibition of FabI, the Enoyl Reductase from Escherichia coli , by Triclosan: Kinetic Analysis of Mutant FabIs †

Sivaraman, Sharada, Zwahlen, Jacque, Bell, Alasdair F., Hedstrom, Lizbeth, Tonge, Peter J.

Journal:

Year:

2003

Language:

english

File:

PDF, 146 KB

english, 2003

17

Guanidine Derivatives Rescue the Arg418Ala Mutation of Tritrichomonas foetus IMP Dehydrogenase †

Guillén Schlippe, Yollete V., Hedstrom, Lizbeth

Journal:

Year:

2005

Language:

english

File:

PDF, 94 KB

english, 2005

18

Inactivation of Cysteine Proteases by (Acyloxy)methyl Ketones Using S‘−P‘ Interactions †

Dai, Yong, Hedstrom, Lizbeth, Abeles, Robert H.

Journal:

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

19

Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis

Close, Dan M., Cooper, Connor J., Wang, Xingyou, Chirania, Payal, Gupta, Madhulika, Ossyra, John R., Giannone, Richard J., Engle, Nancy, Tschaplinski, Timothy J., Smith, Jeremy C., Hedstrom, Lizbeth,

Journal:

Molecular Microbiology

Year:

2019

File:

PDF, 796 KB

2019

20

A novel mechanism of mycophenolic acid resistance in the protozoan parasite tritrichomonas foetus

Lizbeth Hedstrom, Kam-Sing Cheung, Ching C. Wang

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.18 MB

english, 1990

21

Engineering the S1‘ Subsite of Trypsin: Design of a Protease Which Cleaves between Dibasic Residues †

Kurth, Torsten, Grahn, Sibylla, Thormann, Michael, Ullmann, Dirk, Hofmann, Hans-Jörg, Jakubke, Hans-Dieter, Hedstrom, Lizbeth

Journal:

Year:

1998

Language:

english

File:

PDF, 147 KB

english, 1998

22

Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles

Schellenberger, Volker, Turck, Christoph W., Hedstrom, Lizbeth, Rutter, William J.

Journal:

Year:

1993

Language:

english

File:

PDF, 659 KB

english, 1993

23

Allosteric Activation via Kinetic Control: Potassium Accelerates a Conformational Change in IMP Dehydrogenase

Riera, Thomas V., Zheng, Lianqing, Josephine, Helen R., Min, Donghong, Yang, Wei, Hedstrom, Lizbeth

Journal:

Year:

2011

Language:

english

File:

PDF, 4.14 MB

english, 2011

24

Mushroom Tyrosinase Oxidizes Tyrosine-Rich Sequences to Allow Selective Protein Functionalization

Marcus J. C. Long, Prof. Lizbeth Hedstrom

Journal:

Year:

2012

Language:

english

File:

PDF, 1.61 MB

english, 2012

25

Monovalent Cation Activation in Escherichia coli Inosine 5′-Monophosphate Dehydrogenase

Kathleen M. Kerr, Marguerite Cahoon, Daryl A. Bosco, Lizbeth Hedstrom

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 125 KB

english, 2000

26

Engineering for redesign

Hedstrom, Lizbeth

Journal:

Current Opinion in Structural Biology

Year:

1994

Language:

english

File:

PDF, 440 KB

english, 1994

27

A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase

Sharling, Lisa, Liu, Xiaoping, Gollapalli, Deviprasad R., Maurya, Sushil K., Hedstrom, Lizbeth, Striepen, Boris, Simon, Gary

Journal:

PLoS Neglected Tropical Diseases

Year:

2010

Language:

english

File:

PDF, 921 KB

english, 2010

28

Adaptive evolution of drug targets in producer and non-producer organisms

Hansen, Bjarne G., Sun, Xin E., Genee, Hans J., Kaas, Christian S., Nielsen, Jakob B., Mortensen, Uffe H., Frisvad, Jens C., Hedstrom, Lizbeth

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 943 KB

english, 2012

29

Dynamic Characteristics of Guanosine-5′-monophosphate Reductase Complexes Revealed by High-Resolution 31 P Field-Cycling NMR Relaxometry

Rosenberg, Masha M., Redfield, Alfred G., Roberts, Mary F., Hedstrom, Lizbeth

Journal:

Year:

2018

Language:

english

File:

PDF, 2.75 MB

english, 2018

30

Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor

Long, Marcus J.C., Lawson, Ann P., Baggio, Rick, Qian, Yu, Rozhansky, Lior, Fasci, Domenico, El Oualid, Farid, Weerapana, Eranthie, Hedstrom, Lizbeth

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 3.29 MB

english, 2018

31

Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

Gorla, Suresh Kumar, Kavitha, Mandapati, Zhang, Minjia, Chin, James En Wai, Liu, Xiaoping, Striepen, Boris, Makowska-Grzyska, Magdalena, Kim, Youngchang, Joachimiak, Andrzej, Hedstrom, Lizbeth, Cuny,

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 710 KB

english, 2013

32

Deletion of Ile1 Changes the Mechanism of Streptokinase: Evidence for the Molecular Sexuality Hypothesis †

Wang, Shunguang, Reed, Guy L., Hedstrom, Lizbeth

Journal:

Year:

1999

Language:

english

File:

PDF, 161 KB

english, 1999

33

Novel Methylenephosphophosphonate Analogues of Mycophenolic Adenine Dinucleotide. Inhibition of Inosine Monophosphate Dehydrogenase

Rejman, Dominik, Olesiak, Magda, Chen, Liqiang, Patterson, Steven E., Wilson, Daniel, Jayaram, Hiramagalur N., Hedstrom, Lizbeth, Pankiewicz, Krzysztof W.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 93 KB

english, 2006

34

Converting Trypsin to Chymotrypsin: Residue 172 Is a Substrate Specificity Determinant

Hedstrom, Lizbeth, Perona, John J., Rutter, William J.

Journal:

Year:

1994

Language:

english

File:

PDF, 822 KB

english, 1994

35

Converting Trypsin to Chymotrypsin: Ground-State Binding Does Not Determine Substrate Specificity

Hedstrom, Lizbeth, Farr-Jones, Shauna, Kettner, Charles A., Rutter, William J.

Journal:

Year:

1994

Language:

english

File:

PDF, 770 KB

english, 1994

36

IMP Dehydrogenase-Linked Retinitis Pigmentosa

Hedstrom, Lizbeth

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2008

Language:

english

File:

PDF, 1.34 MB

english, 2008

37

Multivalent Glycocluster Design through Directed Evolution

Dr. Iain S. MacPherson, J. Sebastian Temme, Sevan Habeshian, Dr. Krzysztof Felczak, Prof. Krzysztof Pankiewicz, Lizbeth Hedstrom, Prof. Isaac J. Krauss

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

38

ChemInform Abstract: IMP Dehydrogenase: Structure, Mechanism, and Inhibition

Lizbeth Hedstrom

Journal:

Year:

2009

File:

PDF, 15 KB

2009

39

Specific biotinylation of IMP dehydrogenase

B. Christopher Hoefler, Deviprasad R. Gollapalli, Lizbeth Hedstrom

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 231 KB

english, 2011

40

Activating a Zymogen without Proteolytic Processing: Mutation of Lys15 and Asn194 Activates Trypsinogen †

Pasternak, Annette, Liu, Xiaolin, Lin, Tiao-Yin, Hedstrom, Lizbeth

Journal:

Year:

1998

Language:

english

File:

PDF, 148 KB

english, 1998

41

Crystal Structure of a Ternary Complex of Tritrichomonas foetus Inosine 5‘-Monophosphate Dehydrogenase: NAD + Orients the Active Site Loop for Catalysis †,‡

Gan, Lu, Petsko, Gregory A., Hedstrom, Lizbeth

Journal:

Year:

2002

Language:

english

File:

PDF, 165 KB

english, 2002

42

3-Deoxy-D-manno-octulosonate-8-phosphate synthase catalyzes the C-O bond cleavage of phosphoenolpyruvate

Lizbeth Hedstrom, Robert Abeles

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 248 KB

english, 1988

43

Spectrum and Frequency of Mutations in IMPDH1 Associated with Autosomal Dominant Retinitis Pigmentosa and Leber Congenital Amaurosis

Bowne, Sara J., Sullivan, Lori S., Mortimer, Sarah E., Hedstrom, Lizbeth, Zhu, Jingya, Spellicy, Catherine J., Gire, Anisa I., Hughbanks-Wheaton, Dianna, Birch, David G., Lewis, Richard A., Heckenlive

Journal:

Investigative Ophthalmology & Visual Science

Year:

2006

Language:

english

File:

PDF, 790 KB

english, 2006

44

Inhibition of Inosine-5′-monophosphate Dehydrogenase from Bacillus anthracis : Mechanism Revealed by Pre-Steady-State Kinetics

Wei, Yang, Kuzmič, Petr, Yu, Runhan, Modi, Gyan, Hedstrom, Lizbeth

Journal:

Year:

2016

Language:

english

File:

PDF, 434 KB

english, 2016

45

Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis

Close, Dan M., Cooper, Connor J., Wang, Xingyou, Chirania, Payal, Gupta, Madhulika, Ossyra, John R., Giannone, Richard J., Engle, Nancy, Tschaplinski, Timothy J., Smith, Jeremy C., Hedstrom, Lizbeth,

Journal:

Molecular Microbiology

Year:

2019

Language:

english

File:

PDF, 796 KB

english, 2019

46

Species-Specific Inhibition of Inosine 5‘-Monophosphate Dehydrogenase by Mycophenolic Acid †

Digits, Jennifer A., Hedstrom, Lizbeth

Journal:

Year:

1999

Language:

english

File:

PDF, 108 KB

english, 1999

47

Converting Trypsin to Chymotrypsin: Structural Determinants of S1‘ Specificity †

Kurth, Torsten, Ullmann, Dirk, Jakubke, Hans-Dieter, Hedstrom, Lizbeth

Journal:

Year:

1997

Language:

english

File:

PDF, 199 KB

english, 1997

48

Inosine 5′-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo

McLEAN, Jeremy E., HAMAGUCHI, Nobuko, BELENKY, Peter, MORTIMER, Sarah E., STANTON, Martin, HEDSTROM, Lizbeth

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 229 KB

english, 2004

49

Short-lived protease–serpin complexes: Partial disruption of the rat trypsin active site

Lu Liu, Nicole Mushero, Lizbeth Hedstrom, Anne Gershenson

Journal:

Protein Science

Year:

2007

Language:

english

File:

PDF, 621 KB

english, 2007

50

Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase from Cryptosporidium parvum

Johnson, Corey R., Gorla, Suresh Kumar, Kavitha, Mandapati, Zhang, Minjia, Liu, Xiaoping, Striepen, Boris, Mead, Jan R., Cuny, Gregory D., Hedstrom, Lizbeth

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 592 KB

english, 2013

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